Absence of Serum-Stimulated Lipase Activity and Altered Lipid Content in Milk from a Patient with Type I Hyperlipoproteinaemia

Autor: Berger, G M B, Spark, A, Baillie, P M, Huskisson, J, Stockwell, G, Van Der Merwe, E
Zdroj: Pediatric Research; October 1983, Vol. 17 Issue: 10 p835-841, 7p
Abstrakt: Summary: We measured the serum-stimulated lipase activity, fatty acid content, and various biochemical parameters in the breast milk of a lactating mother suffering from familial lipoprotein lipase deficiency and of healthy control subjects. Serum-stimulated lipase activity was virtually undetectable in milk from our patient and the total fatty acid content was low. The fatty acid composition differed from normal showing a marked absolute and relative increase in the content of lauric (C12:0) and myristic (C14:0) fatty acids and considerably reduced levels of oleic (C18:1) and especially linoleic (C18:2) acids. Other fatty acid species showed lesser changes in concentration. Besides a reduced calcium concentration in the milk from our patient, other biochemical parameters were not significantly different from control subjects.
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