| Autor: |
Addonizio, Linda J., Michler, Robert E., Marboe, Charles, Esser, Peter E., Johnson, Lynne L., Seldin, David W., Gersony, Welton M., Alderson, Philip O., Rose, Eric A., Cannon, Paul J. |
| Zdroj: |
Journal of the American College of Cardiology; March 1987, Vol. 9 Issue: 3 p555-564, 10p |
| Abstrakt: |
The acute rejection of cardiac allografts is currently diagnosed by the presence of myocyte necrosis on endomyocardial biopsy. We evaluated the efficacy of noninvasive scintigraphic imaging with indium-111-labeled anticardiac myosin Fab fragments (indium-111 anti-myosin) to detect and quantify cardiac allograft rejection. Six dogs that had intrathoracic heterotopic cardiac allograft transplantation were injected with indium-111 anti-myosin and planar and single photon emission computed tomographic (SPECT) images were obtained in various stages of acute and subacute rejection. Four dogs had an allograft older than 8 months and had been on long-term immunosuppressive therapy; two dogs had an allograft less than 2 weeks old and were not on immunosuppressive therapy. Count ratios comparing heterotopic with native hearts were calculated from both SPECT images and in vitro scans of excised and sectioned hearts and were compared with the degree of rejection scored by an independent histopathologic review. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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