| Autor: |
Ross, Lawrence S., Kandel, Gerald L., Prinz, Leon M., Auletta, Frederick |
| Zdroj: |
Fertility and Sterility; June 1980, Vol. 33 Issue: 6 p618-623, 6p |
| Abstrakt: |
Increasing reports suggest that clomiphene citrate (Clomid) is useful in the treatment of idiopathic hypofertile males. Recent studies have advocated low-dose, cyclic therapy (25mg daily for 25days, 5days’ rest) and, although significant clinical responses have been reported, the hormone response has been erratic. This study of 53 patients, given high-dose, alternate-day therapy (100mg three times/week), shows an over-all positive response rate of 66% and a pregnancy rate of 26%. Significant gonadotropin and testosterone surges were seen in the responders, but a selective lack of a follicle-stimulating hormone surge was noted in a small group of nonresponders. Clomiphene given in this dosage seems to be safe for periods of up to 15months and appears to be a rational and useful agent for the treatment of this patient group. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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