An approach to the synthesis of peptide-PNA-peptide conjugates via native ligation

Autor: Koning, Martijn C. de, Filippov, Dmitri V., Meeuwenoord, Nico, Overhand, Mark, Marel, Gijs A. van der, Boom, Jacques H. van
Zdroj: Tetrahedron Letters; 2002, Vol. 43 Issue: 45 p8173-8176, 4p
Abstrakt: A convenient solid-phase synthesis of a PNA sequence containing an N-terminal thiaproline and a C-terminal thioester is described. The usefulness of this bifunctional PNA molecule is illustrated by the construction, based on native ligation, of a peptide-PNA-peptide adduct.
Databáze: Supplemental Index