Late Recurrent Candida Endocarditis

Autor: Johnston, Putrick G., Lee, James, Domunski, Michael, Dressler, Fred, Tucker, Eben, Rothenberg, Mace, Cunnion, Robert E., Pizzo, Philip A., Walsh, Thomas J.
Zdroj: Chest; June 1991, Vol. 99 Issue: 6 p1531-1533, 3p
Abstrakt: Late recurrent Candida endocarditis (LRCE) developed on a prosthetic mitral valve 22 months after treatment for primary native mitral valve endocarditis. The LRCE was difficult to diagnose; results of two dimensional echocardiography and repeated blood cultures were negative. Only transesophageal echocardiography revealed a vegetation and only lysis centrifugation blood cultures demonstrated candidemia. Postmortem examination revealed a large Candida vegetation on the prosthetic valve and Candida in the mitral valve ring. This case and a review of the literature indicate that Candida endocarditis treated with amphotericin B and prosthetic valve replacement may recur months after treatment, and that LRCE, which is difficult to diagnose and treat, may be best prevented by lifelong antifungal suppressive therapy.
Databáze: Supplemental Index