Effects of Some Psychotropic Agents on Peripheral Nerve Conduction Rate

Autor: Pruett, Jack K., Williams, Byron B.
Zdroj: Journal of Pharmaceutical Sciences; October 1966, Vol. 55 Issue: 10 p1139-1141, 3p
Abstrakt: Impulse conduction rates in isolated frog sciatic nerves were reduced significantly by immersion of the nerves in solutions of chlordiazepoxide, 3.4 × 10−8μm./ml. and prochlorperazine, 5.5 × 10−3μm./ml. Promazine at a concentration of 3.5 × 10−3μm./ml. did not significantly alter conduction rates. For chlordiazepoxide the conduction rate reduction increased with increase in drug concentration.
Databáze: Supplemental Index