Loss of nitroglycerin from solutions to intravenous plastic containers: A theoretical treatment

Autor: Malick, A.Waseem, Amann, Anton H., Baaske, David M., Stoll, Roger G.
Zdroj: Journal of Pharmaceutical Sciences; July 1981, Vol. 70 Issue: 7 p798-800, 3p
Abstrakt: The physical instability of nitroglycerin solutions in plastic containers has been reported extensively. A systematic study of potency loss in plastic infusion bags was reported recently. This paper presents a theoretical treatment of the data and a proposed model consisting of adsorption onto the surface followed by partitioning into the plastic.
Databáze: Supplemental Index