Carbonic Anhydrase Inhibitors. V: Pyrylium Salts in the Synthesis of Isozyme-Specific Inhibitors

Autor: Supuran, Claudiu T., Manole, Gheorghe, Dinculescu, Antonie, Schiketanz, Ana, Gheorghiu, Mircea D., Puscas, Ioan, Balaban, Alexandru T.
Zdroj: Journal of Pharmaceutical Sciences; July 1992, Vol. 81 Issue: 7 p716-719, 4p
Abstrakt: Syntheses and physicochemical properties of 2,4,6-tri-, 2,3,4,6-tetra-, or 2,3,4,5,6-pentasubstituted 1-(2-sulfonamido-1,3,4-thiadiazol-5-yl)pyridinium perchlorates are presented. The new compounds, putative inhibitors of membrane-bound carbonic anhydrase, were tested for inhibitory action on the bovine red cell enzyme.
Databáze: Supplemental Index
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