| Autor: |
Gerulath, Alan H., Borth, Rudi |
| Zdroj: |
American Journal of Obstetrics and Gynecology; August 1977, Vol. 128 Issue: 7 p772-776, 5p |
| Abstrakt: |
Nucleic acid synthesis was studied in 26 tumor specimens, during a one-hour in vitro incubation with the addition of progesterone and estradiol-17β. On the response scale used, deoxyribonucleic acid and ribonucleic acid synthesis decreased linearly as the logarithmic concentration of either hormone increased. Inhibition of nucleic acid synthesis was highly significant (P < 0.001) at 80 μg per milliliter of progesterone and at 40 μg per milliliter of estradiol. No evidence of synergism was found when the two hormones were combined at these concentrations. In Grade I and II tumors, the effect when both hormones were combined approximated the sum of effects of the individual hormones. In Grade III tumors, little difference was seen between treatment groups. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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