| Autor: |
Dixon, Robert, Mbeunkui, Flaubert, Wiegel, Joseph |
| Zdroj: |
Journal of Analytical Science & Technology; December 2015, Vol. 6 Issue: 1 p1-10, 10p |
| Abstrakt: |
The stability of opioids and benzodiazepines was studied in patient urine samples stored at different temperatures over 30 days. Samples were prepared by solid phase extraction and quantified by liquid chromatography coupled to a tandem triple quadrupole mass spectrometer. Sample storage conditions affected the stability of all drugs investigated. The concentrations of hydromorphone and oxymorphone in urine samples from patients who had taken hydrocodone, morphine, and/or oxycodone increased significantly over 30 days of storage. These data suggest that results from long-term-stored urine samples with opioids and benzodiazepines should be cautiously interpreted. This study indicates that the biotransformation of parent drugs to metabolites still occurs during sample storage at ambient temperatures. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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