| Autor: |
Buffington, Charles W., Lechner, Robert B., Martin, William |
| Zdroj: |
Experimental Biology and Medicine; November 1987, Vol. 186 Issue: 2 p218-222, 5p |
| Abstrakt: |
This study explored the hypothesis that coronary vascular injury and dysfunction result from intracoronary administration of Escherichia coliendotoxin (0.025 to 0.4 mg/kg) in dogs. Peak hyperemic coronary flow following a 15-sec period of stopped flow and the maximum flow in response to adenosine were used to estimate coronary vascular reserve. The wet-to-dry ratio of myocardial tissue was used to estimate extravascular water content as an indicator of vascular leak due to endothelial injury. Intracoronary saline was used as a control. Peak reactive hyperemia and maximum flow at constant coronary pressure were not different in the animals receiving intracoronary endotoxin (n= 6) and the animals receiving saline (n= 5) during 4 hr following treatment. In addition, wet-to-dry ratios were similar in these two groups. These data fail to support the hypothesis that endotoxin, per se, produces coronary vascular injury of sufficient magnitude to produce myocardial dysfunction. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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