| Autor: |
Solvonuk, P. F., Jaques, L. B., Leddy, J. E., Trevoy, L. W., Spinks, J. W. T. |
| Zdroj: |
Experimental Biology and Medicine; April 1952, Vol. 79 Issue: 4 p597-603, 7p |
| Abstrakt: |
C14-menadione (2-methyl-C14-1:4-naphthoquinone) was prepared and administered intramuscularly to mice in doses of 1 and 0.1 mg, and to cholecystonephrostomized dogs in a dose of 1 mg/kg. The radioactivity was rapidly absorbed from the injection site and excreted in the urine, with only traces being detected in the blood. Quantities of radioactive material were not stored in any tissue. With the largest dose (1 mg/25 g mouse) a trace of activity was found in the liver and lung. The activity in the urine was attached to a single compound but a second component appeared on mild hydrolysis of the urine.We are greatly indebted to Dr. J. M. Pepper for supervising attempts of one of us (P.S.) to synthesize C14-menadione, to Miss Erica Lepp, who performed the prothrombin times, to Miss R. Keller, who supervised the operating technics, to Mr. D. Wilson for assisting with the radioactivity measurements, to Dr. G. J. Millar for the plasma protein fractionation, to Dr. James Campbell for instruction in catherization technics. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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