Novel cephalosporin derivatives possessing a bicyclic heterocycle at the 3-Position. Part II: Synthesis and antibacterial activity of 3-(5-Methylthiazolo[4,5-c]pyridinium-2-yl)thiomethylcephalosporin derivatives and related compounds

Autor: Tsushima, Masaki, Kano, Yuko, Umemura, Eijiro, Iwamatsu, Katsuyoshi, Tamura, Atsushi, Shibahara, Seiji
Zdroj: Bioorganic & Medicinal Chemistry; September 1998, Vol. 6 Issue: 9 p1641-1653, 13p
Abstrakt: A series of cephalosporin derivatives with a thiazolopyridinium group at the 3-position was synthesized and evaluated for antibacterial activity. Some of these cephalosporin derivatives having a (5-alkylthiazolo[4,5-c]pyridinium-2-yl)thiomethyl group at the 3-position showed strong activity against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. Among them, 5ashowed a good antibacterial spectrum in vitro, and also showed a similar or slightly superior activity to that of ceftazidime in vivo against P. aeruginosa.
Databáze: Supplemental Index
Externí odkaz: