| Autor: |
Durette, Philippe L., Chabin, Renee M., Fletcher, Daniel S., Green, Barbara G., Hanlon, William A., Humes, John L., Knight, Wilson B., Lanza, Thomas J., Mumford, Richard A., Pacholok, Stephen, MacCoss, Malcolm |
| Zdroj: |
Bioorganic & Medicinal Chemistry Letters; 1995, Vol. 5 Issue: 3 p271-274, 4p |
| Abstrakt: |
Analogs of the monocyclic β-lactam human leukocyte elastase (HLE) inhibitor L-680,833 in which the carboxyl group is replaced by phosphorous acid moieties were synthesized and found to be potent inhibitors of the enzyme (kinact/Ki in the range 217,000–1,326,000 M−1s−1). Cellular activity was demonstrated by inhibition of the generation of the N-terminal cleavage product Aα-(1–21) from the Aα chain of fibrinogen. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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