| Autor: |
Chen, Chiann-Mun, Freedman, Jennifer A., Bettler, Donald R., Manning, Sharon D., Giep, Son N., Steiner, Julia, Ellis, Hilary M. |
| Zdroj: |
Mechanisms of Development; July 1996, Vol. 57 Issue: 2 p215-227, 13p |
| Abstrakt: |
Reduction of wild-type activity of the polychaetoid (pyd)gene results in formation of extra mechanosensory bristles on the head and notum of adult Drosophila. Loss of pydfunction results in decreased ability to restrict sensory organ precursor (SOP) formation to a single cell per proneural cluster. Although the initial proneural cluster pattern of achaete expression is not altered in pydmutants extra cells within proneural clusters express the high levels of achaete characteristic of SOPs. This observation suggests that pyd+functions as a negative regulator of achaete-scute complex expression within the proneural cluster. Synergistic interactions between pydand Notch, Deltaand extramacrochaetaemutations support this model. We also demonstrate that pydis required for normal eye development. |
| Databáze: |
Supplemental Index |
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