| Autor: |
Arora, Kriti, Ochoa-Montaño, Bernardo, Tsang, Patricia S., Blundell, Tom L., Dawes, Stephanie S., Mizrahi, Valerie, Bayliss, Tracy, Mackenzie, Claire J., Cleghorn, Laura A. T., Ray, Peter C., Wyatt, Paul G., Uh, Eugene, Lee, Jinwoo, Barry, Clifton E., Boshoff, Helena I. |
| Zdroj: |
Antimicrobial Agents and Chemotherapy; September 2014, Vol. 58 Issue: 11 p6962-6965, 4p |
| Abstrakt: |
ABSTRACTWe report here a series of five chemically diverse scaffolds that have in vitroactivities on replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc1complex in Mycobacterium tuberculosisin a strain-dependent manner. Deletion of the cytochrome bdoxidase generated a hypersusceptible mutant in which resistance was acquired by a mutation in qcrB. These results highlight the promiscuity of the bc1complex and the risk of targeting energy metabolism with new drugs. |
| Databáze: |
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