| Autor: |
Dimitrovska, Aneta, Stojanoski, Kiro, Dorevski, Kiril |
| Zdroj: |
International Journal of Pharmaceutics; March 1995, Vol. 115 Issue: 2 p175-182, 8p |
| Abstrakt: |
Acidic, neutral and alkaline degradation of cefaclor was followed by ultraviolet spectroscopy, high-pressure liquid chromatography and iodometric method. Degradation of the drug follows first-order kinetics under constant pH and temperature conditions. The pH-rate profile was like that of other cephalosporins with an essentially similar structure. Phosphate buffer catalysis was observed. The copper(II)-ion catalyzed hydrolysis of cefaclor was investigated and no significant effect was found. The temperature effects on the reaction rate were followed and from Arrenius plots of the rates of hydrolysis, different activation energies were calculated. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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