Five-chlorodeoxycytidine, a tumor-selective enzyme-driven radiosensitizer, effectively controls five advanced human tumors in nude mice11This paper is dedicated to the memory of Dr. Stephen Zamenhof, the postdoctoral mentor and source of inspiration to S. Greer, and to the memory of Stanley Marion, a devoted and skilled veterinary technician.

Autor:	Greer, Sheldon, Alvarez, Marcy, Mas, Marisol, Wozniak, Chandra, Arnold, David, Knapinska, Anna, Norris, Christina, Burk, Ronald, Aller, Alex, Dauphinée, Michael
Zdroj:	International Journal of Radiation, Oncology, Biology, Physics; November 2001, Vol. 51 Issue: 3 p791-806, 16p
Abstrakt:	Purpose:The study’s goals were as follows: (1) to extend our past findings with rodent tumors to human tumors in nude mice, (2) to determine if the drug protocol could be simplified so that only CldC and one modulator, tetrahydrouridine (H4U), would be sufficient to obtain efficacy, (3) to determine the levels of deoxycytidine kinase and dCMP deaminase in human tumors, compared to adjacent normal tissue, and (4) to determine the effect of CldC on normal tissue radiation damage to the cervical spinal cord of nude mice.
Databáze:	Supplemental Index
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