| Autor: |
Winkler, Jeffrey D., Stelmach, John E., Siegel, Miles G., Haddad, Nizar, Axten, Jeffrey, Dailey, William P. |
| Zdroj: |
Israel Journal of Chemistry; 1997, Vol. 37 Issue: 1 p47-67, 21p |
| Abstrakt: |
The application of the vinylogous amide [2+2] photocycloaddition/retro‐Mannich fragmentation/Mannich closure cascade (pharM) to the synthesis of the pentacyclic ring system of the anti‐leukemic marine alkaloid manzamine A is presented. Two approaches to the synthesis of the requisite pentacycle are described: (a) the transannular photocycloaddition of an 18‐membered vinylogous amide; and (b) photocycloaddition of an acyclic vinylogous amide, followed by macrolactamization of the derived pharMclosure product to generate the pentacyclic ring system. |
| Databáze: |
Supplemental Index |
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