| Autor: |
Nakatani, Tatsuya, Tsuchida, Kenji, Fu, Ontaku, Sugimura, Kazunobu, Takemoto, Yoshiaki |
| Zdroj: |
Blood Purification; 2003, Vol. 21 Issue: 2 p145-151, 7p |
| Abstrakt: |
AbstractBackground/Aim:Blood purification therapies have been clinically applied to treat the cytokine-induced pathological responses. The effects of direct hemoperfusion(DHP) with a β2-microglobulin (BMG) adsorption column on hypercytokinemia were investigated. Methods:A hypercytokinemia model was prepared by injecting lipopolysaccharide (LPS) into femoral veins of male Wistar rats weighing 250–400 g. The hypercytokinemic rats were connected to the DHP system using a small BMG adsorption column, and time course changes in plasma levels of inflammatory cytokines were then examined. Results:Plasma levels of interleukins (IL) 1β and 6 and tumor necrosis factor alpha (TNF-α) were found to be significantly elevated within 3 h after LPS injection in the control group that underwent extracorporeal circulation without the BMG adsorption column, whereas the increases in plasma levels of IL-6 and TNF-α were significantly inhibited in the group that was treated with the BMG adsorption column. The adsorption rates of cytokines with the BMG adsorption column were 20–40% for IL-1β and IL-6 and 10–85% for TNF-α during treatment for 3 h. Conclusions:These results suggest that the systemic inflammatory response syndrome with hypercytokinemia might be treated with DHP using the BMG adsorption column.Copyright © 2003 S. Karger AG, Basel |
| Databáze: |
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