Demethylchlortetracycline in Nonbacterial Pneumonia

Autor: MAISEL, John C., PIERCE, WILLARD E., CRAWFORD, YORK E., FARMER, RICHARD G.
Zdroj: Archives of Internal Medicine; May 1963, Vol. 111 Issue: 5 p547-556, 10p
Abstrakt: INTRODUCTION Empirical antibiotic therapy of nonbacterial pneumonia was attempted sporadically after World War II, but the value of such treatment was long disputed. Summarizing the situation in 1952, Finland commented that the disparities noted between the results of various studies were probably due to variations in both the methods of controlling the clinical observations and the agents causing the illness. He predicted that tetracycline antibiotics would be shown of value in treating primary atypical pneumonia (PAP) due to the Eaton agent.1 The correctness of this opinion is now manifest. Although the syndrome of PAP had been associated with a number of viral infections, the majority of primary atypical pneumonia cases exhibiting the cold agglutinin phenomenon in the serum now may be attributed to the Eaton agent, and the entity, "Eaton agent pneumonia," has been established.2,4 Treatment of "recruit pneumonia" due to the Eaton agent with demethylchlortetracycline was of
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