| Autor: |
Jacob, Howard J., Pettersson, Anna, Wilson, Deborah, Mao, Yipei, Lernmark, Åke, Lander, Eric S. |
| Zdroj: |
Nature Genetics; September 1992, Vol. 2 Issue: 1 p56-60, 5p |
| Abstrakt: |
The BB rat is among the best models of insulin–dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T–cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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