| Autor: |
Goeddel, David V., Yelverton, Elizabeth, Ullrich, Axel, Heyneker, Herbert L., Miozzari, Giuseppe, Holmes, William, Seeburg, Peter H., Dull, Thomas, May, Laurie, Stebbing, Nowell, Crea, Roberto, Maeda, Shuichiro, McCandliss, Russell, Sloma, Alan, Tabor, John M., Gross, Mitchell, Familletti, Phillip C., Pestka, Sidney |
| Zdroj: |
Nature; October 1980, Vol. 287 Issue: 5781 p411-416, 6p |
| Abstrakt: |
A human leukocyte interferon cDNA was enzymatically synthesized, inserted into the vector pBR322, and cloned in Escherichia coli. The DNA sequence codes for a 23-amino acid signal peptide followed by an interferon polypeptide of 165 amino acids. An expression plasmid was constructed which permits the synthesis in E. coli of 2.5 x 108units of interferon per litre of culture. This LeIF protected squirrel monkeys from lethal encephalomyocarditis virus infection. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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