Selective pressure on HL-A polymorphism

Autor: DEGOS, L., COLOMBANI, J., CHAVENTRE, A., BENGTSON, B., JACQUARD, A.
Zdroj: Nature; May 1974, Vol. 249 Issue: 5452 p62-63, 2p
Abstrakt: THE advantages of heterozygotes is one of the most frequent explanations of the maintenance of a polymorphism. This advantage may have the form of a lower fitness of all homozygotes, whatever the allele they possess. According to observations on a small Tuareg isolate, such is apparently the case for the polymorphism of the histocompatibility system HL-A.
Databáze: Supplemental Index