Late-Onset Common Cancers in a Kindred with an Arg213Gln TP53Germline Mutation

Autor: Ruijs, Mariëlle, Verhoef, Senno, Wigbout, Gea, Pruntel, Roelof, Floore, Arno, Jong, Daphne, Veer, Laura, Menko, Fred
Zdroj: Familial Cancer; June 2006, Vol. 5 Issue: 2 p169-174, 6p
Abstrakt: Li-Fraumeni syndrome (LFS) is an autosomal-dominant condition characterized by early-onset sarcoma, breast cancer and other specific tumour types. In most LFS kindreds germline TP53mutations have been identified. In general, TP53germline mutations are not associated with late-onset common cancers. We encountered a large kindred in which a wide spectrum of tumour types occurred, including melanoma, breast, ovarian, colorectal, stomach and renal cell cancer, without clear-cut early ages at onset of disease. An Arg213Gln TP53germline mutation was detected in 12 out of 15 affected family members whereas testing for other cancer susceptibility genes in selected patients was negative. In vitrotesting indicated that the specific TP53mutation inactivates the protein transcriptionally. Our findings suggest that this TP53germline mutation is a causative factor in this family and that specific TP53germline mutations can be associated with relatively late-onset common cancers.Li-Fraumeni syndrome (LFS) is an autosomal-dominant condition characterized by early-onset sarcoma, breast cancer and other specific tumour types. In most LFS kindreds germline TP53mutations have been identified. In general, TP53germline mutations are not associated with late-onset common cancers. We encountered a large kindred in which a wide spectrum of tumour types occurred, including melanoma, breast, ovarian, colorectal, stomach and renal cell cancer, without clear-cut early ages at onset of disease. An Arg213Gln TP53germline mutation was detected in 12 out of 15 affected family members whereas testing for other cancer susceptibility genes in selected patients was negative. In vitrotesting indicated that the specific TP53mutation inactivates the protein transcriptionally. Our findings suggest that this TP53germline mutation is a causative factor in this family and that specific TP53germline mutations can be associated with relatively late-onset common cancers.
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