| Autor: |
Palmer, James L., Knudsen, Martin S., Aagren, Mark, Thomsen, Trine L. |
| Zdroj: |
Journal of Medical Economics; June 2010, Vol. 13 Issue: 2 p212-220, 9p |
| Abstrakt: |
Objectives:To evaluate the cost-effectiveness of switching to biphasic insulin aspart (BIAsp 30) from human premix insulin for type 2 diabetes patients in the United States (US) setting.Methods:The previously published and validated IMS Core Diabetes Model was used to project life expectancy, quality-adjusted life expectancy (QALE) and costs over 30 years. Patient characteristics and treatment effects were based on Canadian patients included the IMPROVE observational study (n 311). Mean glycohaemoglobin (HbA1c) was 8.4, duration of diabetes 16 years and prevalence of complications high at baseline. Simulations were conducted from the perspective of a third-party payer, with costs accounted in 2008 US dollars ().Results:BIAsp 30 was projected to improve life expectancy by 0.202 years and QALE by 0.301 quality-adjusted life-years (QALYs), due to a reduced incidence of most diabetes-related complications. BIAsp 30 was associated with increased lifetime direct medical costs (76,517 vs. 67,518) and an incremental cost-effectiveness ratio of 29,870 per QALY gained. Long-term outcomes were sensitive to the impact of BIAsp 30 on hypoglycaemia and changes in HbA1c.Conclusions:BIAsp 30 may represent a cost-effective treatment option in the US setting for advanced type 2 diabetes patients experiencing poor glycaemic control or hypoglycaemia on human premix insulin.Limitations:The application of treatment effect data derived from a Canadian cohort to the US setting was a limitation of the cost-effectiveness analysis. The findings of this cost-effectiveness analysis are not applicable to insulin-naïve diabetes patients. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
