| Abstrakt: |
The synthesis of several 1,2diaryl1H4,5,6,7tetrahydro1,3diazepines 1by cyclization of NarylNbenzoyltetramethylenediamines 2is described. Two alternative synthetic routes to obtain precursors 2are discussed, being that which employes pyrrolidine as starting material the most convenient. Nucleophilic attack of compounds 1on methyl iodide affords 1,2diaryl1H4,5,6,7tetrahydro1,3diazepinium iodides 3. 1Hnmr spectra of these compounds are unequivocally assigned by means of NOESY experiments, 1Hnmr spectra of compounds 1and 3are analyzed and compared inter seand with those of compounds 1run in the presence of trifluoroacetic acidd. Reduction of compounds 1with borane leads regiospecifically to NaralkylNaryltetramethylenediamines 7. |
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