| Autor: |
Spawinska, B., Furmaga, W., Kuzniar, J., Stawiarski, M., Pikor, I., Szmigiel, Z., Spawinski, J. |
| Zdroj: |
Scandinavian Journal of Clinical and Laboratory Investigation; 1987, Vol. 47 Issue: 2 p125-130, 6p |
| Abstrakt: |
The de-aggregatory effect of prostacyclin (PGI2) and the rate of spontaneous platelet aggregation (SPA) were studied in vitroin whole blood of 24 males with acute myocardial infarction (MI) and 18 males, patient controls (PC). The de-aggregatory effect of PGI2and the rate of SPA (measured as a percentage of changes in free platelet number in whole blood) were higher (p<0.01) in MI than PC. The de-aggregatory effect of PGI2in whole blood was higher (p<0.05) on the first day of MI than on day 14 following MI. The highest de-aggregatory effect of PGI2was found in whole blood of patients with MI complicated by ventricular fibrillation. In neither of the groups did the de-aggregatory effect of PGI2correlate with patients' age, haematocrit, erythrocyte and leucocyte counts, triglycerides, HDL, LDL or total cholesterol levels. In the MI group, de-aggregatory effect of PGI2was correlated with free platelet concentration (r-0.59, p<0.05), elevation of glutamic oxalacetic transaminase (r0.53, p<0.05) and creatinine Phosphokinase (r0.69, p<0.001). The de-aggregatory effect of PGI2in blood of patients with evolving MI did not differ from that in PC. It is concluded that the increased rate of SPA and formation of PGI2-sensitive platelet aggregates in vitroin whole blood of MI patients are secondary to myocardial necrosis. |
| Databáze: |
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