| Autor: |
Spawinska, B., Furmaga, W., Nieszpaur, M., Ziembicki, W., Kuzniar, J., Duska, Z., Rybak, A., Spawinski, J. |
| Zdroj: |
Scandinavian Journal of Clinical and Laboratory Investigation; 1987, Vol. 47 Issue: 2 p119-124, 6p |
| Abstrakt: |
When unstirred citrated blood of young males was left to stand at 21 °C, the number of free platelets decreased as measured with a whole blood platelet counter. This decrease indicated spontaneous platelet aggregation (SPA) since it was accompanied by the time-dependent increase in platelet micro-aggregates and plasma beta-thromboglobulin while lactate dehydrogenase level did not change significantly. Addition of PGI2to whole blood increased free platelet count and decreased the number of platelet micro-aggregates. The de-aggregatory effect of PGI2(measured as a percentage increase in free platelet number) was correlated with the initial amount of platelet micro-aggregates. Blood storage enhanced SPA and de-aggregatory effect of prostacyclin. Immediately after blood collection de-aggregatory effect of prostacyclin was absent. Our results favour an assumption that prostacyclin-sensitive platelet aggregates in blood of young volunteers are formed in vitrorather than in vivo. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
