| Autor: |
VAN RENSBURG, S. J., POTOCNIK, F.C. V., DE VILLIERS, J.N. P., KOTZE, M. J., TALJAARD, J.J. F. |
| Zdroj: |
Annals of the New York Academy of Sciences; April 2000, Vol. 903 Issue: 1 p200-203, 4p |
| Abstrakt: |
The etiology of Alzheimer's disease is now known to be multifactorial. The genetic factors transferrin C2 (TfC2) and apolipoprotein E 4 (ApoE-4) have both been associated with Alzheimer's disease (AD). Transferrin is the carrier protein for iron in the blood, while ApoE is involved with the transport and redistribution of lipids. In the present study, the polymerase chain reaction (PCR) method was used to determine the frequency of both TfC2 and ApoE-4 in 27 AD patients, 9 vascular dementia (VaD) patients, and 27 controls. Patients were diagnosed according to the criteria as set out in the 4th edition of the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV). |
| Databáze: |
Supplemental Index |
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