| Autor: |
Wada, C. K., Holms, J. H., Curtin, M. L., Dai, Y., Florjancic, A. S., Garland, R. B., Guo, Y., Heyman, H. R., Stacey, J. R., Steinman, D. H., Albert, D. H., Bouska, J. J., Elmore, I. N., Goodfellow, C. L., Marcotte, P. A., Tapang, P., Morgan, D. W., Michaelides, M. R., Davidsen, S. K. |
| Zdroj: |
Journal of Medicinal Chemistry; January 2002, Vol. 45 Issue: 1 p219-232, 14p |
| Abstrakt: |
A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matrix metalloproteinases (MMP) inhibitors. The substitution of the ether linkage of ABT-770 (5) with a sulfone group 13a led to a substantial increase in activity against MMP-9 but was accompanied by a loss of selectivity for inhibition of MMP-2 and -9 over MMP-1 and diminished oral exposure. Replacement of the biphenyl P1 substituent with a phenoxyphenyl group provided compounds that are highly selective for inhibition of MMP-2 and -9 over MMP-1. Optimization of the substituent adjacent to the retrohydroxamate center in this series led to the clinical candidate ABT-518 (6), a highly potent, selective, orally bioavailable MMP inhibitor that has been shown to significantly inhibit tumor growth in animal cancer models. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
