| Autor: |
Poisson, Thomas, Gembus, Vincent, Oudeyer, Sylvain, Marsais, Francis, Levacher, Vincent |
| Zdroj: |
The Journal of Organic Chemistry; 20240101, Issue: Preprints p3516-3519, 4p |
| Abstrakt: |
The first transition-metal-free addition of alkyl nitriles to unactivated imines was developed using a catalytic combination of 4-MeOC6H4ONa and TMSCH2CO2Et to promote the reaction. The corresponding β-amino nitriles are obtained in good to almost quantitative isolated yields under mild conditions. A mechanism involving an autocatalytic pathway is proposed on the basis of experimental observations. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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