| Autor: |
Signore, Alberto, Annovazzi, Alessio, Gradini, Roberto, Liddi, Roberto, Ruberti, Giovina |
| Zdroj: |
Diabetes / Metabolism Reviews; September 1998, Vol. 14 Issue: 3 p197-206, 10p |
| Abstrakt: |
The relationship between Fas-mediated apoptosis and Type 1 diabetes is currently under investigation. Fas/Fas ligand interaction could be involved both in the insulitis process and in β-cell death. Nevertheless, different mechanisms appear to be involved in human Type 1 diabetes and in NOD mice. In the present work, we review recent evidence of the role of the Fas/Fas ligand system in human and NOD mouse diabetes, describing possible hypotheses for its involvement in the pathogenesis of the disease, with possible implications for therapy and islet transplantation. Copyright © 1998 John Wiley & Sons, Ltd. |
| Databáze: |
Supplemental Index |
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