| Autor: |
Fiorucci, Stefano, Distrutti, Eleonora, Quintieri, Adolfo, Sarpi, Lucio, Spirchez, Zeno, Gulla, Nino, Morelli, Antonio |
| Zdroj: |
Digestive Diseases and Sciences; June 1995, Vol. 40 Issue: 6 p1365-1371, 7p |
| Abstrakt: |
There is recent evidence that nitric oxide, a soluble gas produced froml-arginine, is released by the smooth muscle cells and neurons of the gastrointestinal tract where it exerts a myorelaxive action. However, little is known about the effects nitric oxide has on gastric and gallbladder motility during the inter- and postprandial phases in man. We therefore investigated the effects 200 mg/kg/hrl-arginine exerts on the gastric and gallbladder motility induced by 2 mg/kg erythromycin or a liquid meal in 21 subjects in a double-blind, placebo-controlled study. Gastric and gallbladder emptying were evaluated by sonography. Fasting antral motility was expressed as antral motility index (MI). In fasting subjects,l-arginine administration determined a threefold increase in plasma nitrite concentrations. Administration of erythromycin caused a significant rise in the antral MI, which was inhibited byl-arginine (P<0.05). Ingestion of a liquid meal also significantly increased antral MI, but it returned to basal values 90 min after the end of the meal. Althoughl-arginine administration caused a significant reduction in the antral MI (P<0.05), it did not inhibit gastric emptying.l-Arginine provoked an approximately 40% increase in basal gallbladder volume, completely blocked erythromycin-induced emptying, and partially, but significantly, prevented the emptying induced by a liquid meal (P<0.01). Our study suggests that nitric oxide may be implicated in the physiological modulation of gastric and gallbladder motility during the inter-and postprandial phases in man. |
| Databáze: |
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