Morphology of experimental acute pancreatitis during treatment with 5-fluorouracil

Autor: Nishanov, Kh. T., Kaem, R. I.
Zdroj: Bulletin of Experimental Biology and Medicine; March 1980, Vol. 89 Issue: 3 p385-387, 3p
Abstrakt: In experimental pancreatitis induced by a modified method (Arai, 1965) 5-fluorouracil has a marked therapeutic action, preventing the development of necrosis of the acini and suppurative liquefaction of the gland tissue. The authors attribute the therapeutic effect of 5-fluorouracil to its inhibitory action on RNA synthesis and blockade of the liberation of secretion from the exocrine part of the pancreas.
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