| Abstrakt: |
The effect of uridine and cytidine on the course of repair processes in the liver of rats with experimental hepatitis due to CCl4 was studied. Injection of uridine or cytidine simultaneously with CCl4 over a period of 7 days did not prevent damage to the liver by the poison. Further treatment with the nucleosides (up to 15 and 20 days) accelerated, although to different degrees, the course of repair processes after discontinuation of CCl4. Cytidine, for instance, caused marked hypertrophy of regenerating hepatocytes, combined with proliferation of mesenchymal cells, which, however, was not accompanied by restoration of the conjugating and excretory functions of the liver. Unlike cytidine, uridine led to more rapid normalization of the abovementioned functions, although restoration of the structure of the organ in this case was less complete. |
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