| Autor: |
Motyl, T., Kasterka, M., Grzelkowska, K., Blachowski, S., Sysa, P. |
| Zdroj: |
Annals of Hematology; December 1993, Vol. 67 Issue: 6 p285-288, 4p |
| Abstrakt: |
Summary The present study proved that TGF-ß1 significantly inhibited the growth of K 562 cells. The drop in cell numbers after 24 h incubation with increasing concentrations of TGF-ß1 (0.01, 0.1, 1.0, 10.0 ng/ml) was accompanied by significant suppression of the activity of two key enzymes of polyamine biosynthesis: ornithine decarboxylase (ODC) and S-adenosylme-thionine decarboxylase (SAMDC). In contrast to ODC and SAMDC activity, TGF-ß1 did not significantly affect the absolute concentration of spermidine and spermine in K 562 cells. We suppose that the lack of an evident drop in concentration of spermidine and spermine in spite of a significant decrease in ODC and SAMDC activity in K 562 cells exposed to TGF-ß1 resulted from the uptake of polyamines from the extracellular space. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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