| Autor: |
Tse, S. Y. H., Wei, E. T. |
| Zdroj: |
Psychopharmacology; October 1986, Vol. 90 Issue: 3 p322-326, 5p |
| Abstrakt: |
Shaking movements, similar to those made by a dog when wet, were elicited in rats by a) immersion in ice-water, b) injections of icilin, a chemical that produces sensations of cold, and c) naloxone-precipitated morphine withdrawal. Adenosine and 2-chloroadenosine produced dose-dependent inhibition of shaking to ice-water and icilin. The 2-chloroadenosine effect was mediated centrally because the ICV dose required to produce inhibition was not effective when given IP. Caffeine antagonized the inhibitory effects of adenosine and 2-chloroadenosine. 2-Chloroadenosine suppressed morphine-abstinence shaking as well as the body weight loss that normally accompanies withdrawal. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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