| Autor: |
Bloch, Michael H., LanderosWeisenberger, Angeli, Sen, Srijan, Dombrowski, Philip, Kelmendi, Ben, Coric, Vladimir, Pittenger, Christopher, Leckman, James F. |
| Zdroj: |
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; September 2008, Vol. 147 Issue: 6 p850-858, 9p |
| Abstrakt: |
We investigated the association between the long l and short s alleles of the serotonin transporter polymorphism 5HTTLPR in the promoter region of the SLC6A4gene and obsessivecompulsive disorder OCD using metaanalysis to combine all published data from case–control and family based association studies 2,283 cases. In stratified metaanalysis we investigated whether age of sample child and adult, ethnicity Caucasian and Asian and study design case–control and familybased association studies moderated any association. In the overall metaanalysis we found no evidence of association between genetic variation at the 5HTTLPR locus and OCD. We did find significant heterogeneity between studies. In the stratified metaanalyses, we demonstrated a significant association between the lallele and OCD in familybased association studies and in studies involving children and Caucasians. Our metaanalysis suggests the possibility that the lallele may be associated with OCD in specific OCD subgroups such as childhoodonset OCD and in Caucasians. Further metaanalyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness e.g., tics moderates the relationship between 5HTTLPR and OCD. © 2008 WileyLiss, Inc. |
| Databáze: |
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