CT in neuromuscular disorders: a comparison of CT and histology

Autor: vd Vliet, A. M., Thijssen, H. O. M., Joosten, E., Merx, J. L.
Zdroj: Neuroradiology; November 1988, Vol. 30 Issue: 5 p421-425, 5p
Abstrakt: The value of CT-examination of the muscles compared to histology was studied in a retrospective analysis of 30 patients with clinical suspicion of neuromuscular disorder. In the evaluation of the CT-results descriptive criteria were used. The histologic diagnosis came from needle-biopsies taken from the quadriceps muscle. Considering the whole group of neuromuscular disorders, CT has an overall accuracy of 84.8%, a positive predictive value of 95.5% and a negative predictive value of 63.6%. This makes the use of CT as a diagnostic tool in neuromuscular disorders a reliable examination technique. In patients with a polymyositis there is even a 100% correlation between CT findings and biopsy results. Discrepancy between the biopsy results of the quadriceps muscle and the CT findings is remarkable: the number of abnormal histological findings is twice the number of abnormal CT findings. Using the more proximal gluteal region as a biopsy site would have decreased this discrepancy and would therefore have given a better correlation between CT and histology.
Databáze: Supplemental Index