| Abstrakt: |
Summary The operation of a seven-compartment model is described with respect to flows of Na+ within and across this system, simulating published results obtained on frog skin. The seven compartments represent: one outside and one inside solution compartment; the subcorneal space; the first reacting cell layer (1. RCL); the remaining cell compartment; the non-, or slowly exchangeable Na+ compartment; the extracellular space. Assuming reasonable volumes for the epidermal compartments and further chosing, by trial and error, appropriate rate constants, a set of seven simultaneous linear differential equations was solved by the application of the Continuous System Modeling Program (CSMP), using an IBM 1130 computer. Initial conditions for influx, backflux and net flux were taken which correspond to [Na+]0; [Na+]i=115mm. Print-out data were obtained at 0.5-min intervals for 30 min, when steady states were obtained in 13 models studied, varying certaink's thus simulating actions of chemical agents (hormones; drugs). Simulation was achieved with regard to rate of influx, backflux and net flux, steady-state time (30 min), and electrical potentials. In addition, this approach gave detailed information on Na+ pool sizes and their variations with changes ink's. These results are compared to published data on frog skin and good agreement between operation of skin epidermis and model was found. |
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