| Autor: |
Lingg, Robert D., Kaylor, William H., Pyle, Steven M., Domino, Mark M., Smith, Carl C., Wolfe, Geraldine F. |
| Zdroj: |
Archives of Environmental Contamination and Toxicology; March 1982, Vol. 11 Issue: 2 p173-183, 11p |
| Abstrakt: |
Male rats were given single peroral doses of bis(1-14C-2-chloroethyl)ether ([1-14C]BCEE) (40 mg/kg) and of bis(1-14C-2-chloroisopropyl)ether ([1-14C]BCIE) (90 mg/kg). Excretion of14CO2 and urinary14C was followed for 48 hr. The time required to eliminate one half of the dose was 12 hr for [1-14C]BCEE and 19 hr for [1-14C]BCIE. In the case of [1-14C]BCEE, expired14CO2 accounted for 11.5 ± 5.6(SD) % of the dose, urinary14C accounted for 64.7 ± 14.8%, and 2.4 ± 1.3% was found in the feces. The figures for [1-14C]BCIE were 20.3 ± 9.4% expired as14CO2, 47.5 ± 8.1% as urinary14C, and 3.8 ± 0.3% as fecal14C. Thiodiglycolic acid (TDGA) accounted for roughly 75% of the total urinary14C collected after the [1-14C]BCEE dose. Lesser metabolites of BCEE were 2-chloroethoxyacetic acid (CEAA) (5%), and N-acetyl-S-[2-(2-chloroethoxy)ethyl]-L-cysteine (ACEEC) (7%). Metabolites of [1-14C]BCIE identified in rat urine were 2-(2-chloro-1-methylethoxy)propanoic acid (CMEPA), roughly 36% of the total urinary14C, and N-acetyl-S-(2-hydroxypropyl)-L-cysteine (AHPC) at 19%. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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