| Autor: |
Rodda, Bruce E., Chernish, Stanley M., Nash, J. Frank |
| Zdroj: |
Journal of Pharmacokinetics and Pharmacodynamics; June 1976, Vol. 4 Issue: 3 p243-253, 11p |
| Abstrakt: |
Many prolonged-release preparations are designed so that a certain fraction is immediately available for absorption upon administration, while the remainder becomes available for absorption at an effectively constant rate. Recently, a number of prolonged-release propoxyphene hydrochloride formulations have been designed to dissolve in this manner in vitro.We employed a pharmacokinetic model, product dissolution data, and historical plasma concentration data to predict the plasma propoxyphene concentrations which might result from a particular mix and thus minimize the number of formulations requiring evaluation in subjects. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink