| Autor: |
Crider, A. M., Liu, S., Li, T., Mahajan, S., Ankersen, M., Stidsen, C. E. |
| Zdroj: |
Letters in Drug Design & Discovery; January 01, 2004, Vol. 1 Issue: 1 p84-87, 4p |
| Abstrakt: |
Thiourea analogues of NNC 26-9100 (2) were prepared as somatostatin receptor subtype 4 (sst4) ligands. The indole 9 exhibited high affinity (Ki = 23 nM) and about a 100-fold selectivity at sst4 compared to sst2 receptors. The (imidazol-4-yl) propyl group appears to play a major role in the affinity and selectivity of these thioureas at sst4. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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