Histamine2-Receptor Antagonists in Gastroduodenal Ulcer Haemorrhage

Autor: Falk, A., Darle, N., Haglund, U., Törnqvist, A.
Zdroj: Scandinavian Journal of Gastroenterology; 1985, Vol. 20 Issue: 0 p95-100, 6p
Abstrakt: This paper reviews randomised trials in which the effects of histamine2-receptor antagonists have been studied in gastroduodenal ulcer haemorrhage. There is a trend in these studies that histamine2-receptor antagonists may reduce the number of rebleedings, especially in elderly patients with gastric ulcers. A randomised trial comparing cimetidine and ranitidine in high risk patients with massive gastroduodenal haemorrhage is also presented. The total mortality in this study was 12%, 15% for gastric ulcer patients and 11 % for duodenal ulcer patients. There was no difference in mortality, amount of blood transfusion required, rebleedings or need for emergency surgery between the two treatment models.
Databáze: Supplemental Index