| Autor: |
M. Boot, Claudia, C. Gassner, Nadine, E. Compton, Jennifer, Tenney, Karen, M. Tamble, Craig, Scott Lokey, R., R. Holman, Theodore, Crews, Phillip |
| Zdroj: |
Journal of Natural Products; September 2007, Vol. 70 Issue: 10 p1672-1675, 4p |
| Abstrakt: |
A new compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin, 11- O-methylpseurotin A ( 1), was identified from a marine-derived Aspergillus fumigatus. Bioassay-guided fractionation using a yeast halo assay with wild-type and cell cycle-related mutant strains of Saccharomyces cerevisiaeresulted in the isolation of 1, which selectively inhibited a Hof1 deletion strain. Techniques including 1D and 2D NMR, HRESIMS, optical rotation, J-based analysis, and biosynthetic parallels were used in the elucidation of the planar structure and absolute configuration of 1. A related known compound, pseurotin A ( 2), was also isolated and found to be inactive in the yeast screen. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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