A prospective study of the effect of botulinum toxin A on masseteric muscle hypertrophy with ultrasonographic and electromyographic measurement

Autor: To, E.W.H., Ho, W.S., Wong, W.K., Pang, P.C.W., Ahuja, A.T., Hui, A.C.F., King, W.W.K.
Zdroj: British Journal of Plastic Surgery; April 2001, Vol. 54 Issue: 3 p197-200, 4p
Abstrakt: We evaluated the effect of botulinum toxin A on masseteric muscle hypertrophy by using ultrasound andelectromyography. Five patients (four with bilateral and one with unilateral masseteric muscle hypertrophy) were studied prospectively. In each patient, ultrasound-guided percutaneous intramuscular injection of botulinum toxin A was carried out. The change in muscle bulk was evaluated using serial ultrasonography and the electrical activity was assessed with electromyography. All five patients (nine hypertrophic muscles) showed a good response, with the maximal effect of a 31% reduction in muscle bulk seen 3 months after treatment. The effect remained stable one year after injection for six of the hypertrophic muscles, whereas three muscles needed a second injection to maintain the atrophy. This preliminary prospective study suggests that botulinum toxin A is a safe alternative method of treating masseteric muscle hypertrophy. However, the effect may be temporary and further intramuscular injection may be required to maintain atrophy.
Databáze: Supplemental Index