| Autor: |
Gierasch, T. M., Chytil, M., Didiuk, M. T., Park, J. Y., Urban, J. J., Nolan, S. P., Verdine, G. L. |
| Zdroj: |
Organic Letters; December 2000, Vol. 2 Issue: 25 p3999-4002, 4p |
| Abstrakt: |
This report describes a modular approach to the synthesis of stereodiversified natural product-like libraries. Monomers 2 and 3 were coupled in parallel by silyl-tethered olefin metathesis to generate all 16 stereoisomers of cis-enediols 1. All 16 stereoisomers were incorporated into chimerae having flanking peptidic segments. These chimerae exhibited a broad range of hydrophobicities, raising the possibility that stereochemical variation might be used to tune the pharmacologic properties of small molecules. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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