| Autor: |
McKittrick, B. A., Ma, K., Huie, K., Yumibe, N., Davis, H., Jr., Clader, J. W., Czarniecki, M., McPhail, A. T. |
| Zdroj: |
Journal of Medicinal Chemistry; February 26, 1998, Vol. 41 Issue: 5 p752-759, 8p |
| Abstrakt: |
The C3 phenylpropyl side chain of N-phenylazetidinones related to SCH 56524 was modified by replacing the hydroxymethylene with various isoelectronic or isosteric groups. Modifications at the 3 position led to less-active compounds; however, modifications at the 1 position provided compounds with improved cholesterol absorption inhibitory activity. An enantioselective route for the synthesis of C3 1-sulfur-substituted azetidinones and the development of structure−activity relationships for this series of compounds are presented. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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