| Autor: |
Adamo, V., Aiello, R., Altavilla, G., Cammarata, M., Carreca, I., Carroccio, R., Di Carlo, A., Failla, G., Iacono, C., Ianniuo, E., Leonardi, V., Pagliarello, F., Palmeri, S., Tarantino, G., Vitello, S. |
| Zdroj: |
European Journal of Cancer; November 1995, Vol. 31 Issue: 6 pS256-S256, 1p |
| Abstrakt: |
Nausea and Vomiting (N/V) are very frequent side effects of cancer chemotherapy. 5HT3receptors antagonists are new antiemetic drugs that can improve quality of life of cancer patients receiving chemotherapy. We have conducted a multicentric randomized study to compare the efficacy and tolerability of two 5HT3receptors antagonist: OND and GRA. We enrolled 118 non-pretreated cancer pts (70 females, 48 males) to receive OND 0.15mg/kg iv dl (repeated at 2 and 4 hrs) (116 cycles) or GRA 40mcr/kg iv dl (117 cycles) before chemotherapy regimen. Each pt was randomized to receive one of two schedules at first cycle and the other schedule at second cycle. The main patient characteristics were: mean age 51 yrs, KI 0–3.48 (41%) pts received highly emetogenic chemotherapy (HE), 70 (59%) pts received moderate emetogenic chemotherapy (ME). Thirty-six per cent of pts had breast cancer, 24% lung, 16% LH/LNH, 24% other. Of the total 233 cycles administered (93 HE, 140ME) we have registered the following results: (1) HE regimen: N/V grade (G)1 11% (OND) and 11% (GRA), G2 17% (OND) and 17% (GRA), G3 4% (OND) and 2% (GRA). Seventeen per cent (OND) and 20% (GRA) had not N/Y. (2) ME regimen: N/V grade (G) 1 16% (OND) and 16% (GRA), G2 15% (OND) and 11% (GRA), G3 2% (OND) and 3% (GRA). Seventeen per cent (OND) and 21% (GRA) had not N/V. The main toxicities were: headache 24% (OND) and 23% (GRA), light-headedness 13% (OND) and 18% (GRA), constipation 11% (OND) and 6% (GRA), other 6% (OND) and 6% (GRA). None of these differences were statistically significant. It is to note that each pt was requested to express a preference between the two drugs: 22% of pts chose OND, 38% GRA and 40% expressed no preference. These differences are statistically significant (α=0.05). In conclusion we think that OND and GRA are effective but the two drugs are equally active and toxic. From a subjective point of view we noted a trend in favour of GRA. |
| Databáze: |
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